Alzheimer's disease: exploring the pathogenesis, progression, and strategies for management

Document Type : Review article

Authors

1 Zoology department, Faculty of Science, Aswan University, Aswan, Egypt

2 Aswan University

3 Medical Biochemistry Dep., Faculty Of Medicine, South Valley University, Qena, Egypt

Abstract

Alzheimer’s disease (AD), a devastating neurodegenerative disease with many possible etiologies that have been explained and associated with spatial disorientation, memory loss and the gradual decline of intellectual capacity. The current research on neurodegenerative illnesses has put certain candidate compounds through clinical trials. Many reasons have been linked with the increase of AD risk. The progression of AD is marked by gradual cognitive decline, brain alterations such as decreased information transfer throughout synapses, which results in the death of neurons, thus contributive to the decline of functional and cognitive abilities Early diagnosis, coupled with a better understanding of biomarkers, is crucial for improving patient outcomes and developing targeted therapies. Even though it was first recognized over a century ago, AD is still an incurable disease. Only four medications have been accepted by the European Medicines Agency and the Food and Drug Administration for the treatment of cognitive symptoms; these medications, however, cannot stop or slow the disease's progression, neurodegeneration, or memory loss.

Keywords

Main Subjects

Aswan Science and Technology Bulletin
Volume 3, Issue 1
June 2025
Pages 132-158

Files

Share

How to cite

Statistics